NN1177 (trifluoroacetate salt)

Formulation: A solid

Purity: ≥98%

Formula Markup: C206H323N51O66 • XCF3COOH

Formula Weight: 4570,1

Shelf life (days): 1460

Notes: NN1177 is a dual peptide agonist of the glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-1R).{66867} It induces cAMP production in BHK-21 cells expressing human GCGR or GLP-1R (EC50s = 1.83 and 0.92 pM, respectively). In vivo, NN1177 (3-5 nmol/kg) reduces body weight and cumulative food intake in a mouse model of diet-induced obesity. It also reduces body weight, hepatic fat accumulation and fibrosis, and plasma alanine transaminase (ALT) levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a high-fat, high-fructose, and high-cholesterol diet.{66868}

• SKU: CAY41333-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41333-25
• Package Unit: 25 mg
• Quantity Unit: STK