Formulation: A crystalline solid
Formal Name: 2-[4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)-acetamide
Purity: ≥98%
Formula Markup: C26H32N4O4S
Formula Weight: 496,6
Shelf life (days): 1460
CAS Number: 475086-01-2
Notes: Prostaglandin I2 (PGI2) is a potent vasorelaxant and inhibitor of human platelet aggregation that mediates its actions by binding to a specific G protein-coupled receptor, the IP receptor, on the surface of endothelial cells and platelets.{4375} The IP receptor also participates in signal transduction of the pain response, cardioprotection, and inflammation.{9050,5018,9805,8508,5466} NS 304 is a prodrug of the active form of MRE-269, which is a potent and selective agonist for the human IP receptor with a Ki value of 20 nM.{14998} In contrast to prostaglandin I2, which has a half-life of 30 seconds to a few minutes in vivo, NS 304 is long-acting. Plasma concentrations of MRE-269 remain near peak levels for more than eight hours in rats and dogs after NS 304 was administered orally.{14998}
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