NS 3623, CAS 343630-41-1

Formulation: A solid

Formal Name: N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-N′-[3-(trifluoromethyl)phenyl]-urea

Purity: ≥95%

Formula Markup: C15H10BrF3N6O

Formula Weight: 427,2

Shelf life (days): 1460

CAS Number: 343630-41-1

Notes: NS 3623 is an ion channel modulator.{68007,68008,68009} It inhibits the volume-regulated anion channel (VRAC) in HEK293 cells and chloride conductance in isolated human red blood cells (IC50s = 1.8 and 0.21 µM, respectively).{68007,68008} NS 3623 also activates human-ether-a-go-go (hERG), also known as Kv11.1 (EC50 = 79.4 µM) but does not activate the voltage-gated potassium channel (Kv) subtypes Kv1.5, Kv4.3, or Kv7.1 at 30 µM.{68009} It increases red blood cell density and improves red blood cell morphology in the SAD transgenic mouse model of sickle cell disease when administered at a dose of 100 mg/kg per day for 21 days.{68008} NS 3623 (50 mg/kg) reverses QT interval prolongation induced by the hERG inhibitor E-4031 (Item No. 15203) in conscious guinea pigs.{68010}

• SKU: CAY34992-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 34992-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK
• Application: Reinstoffe