Formulation: A crystalline solid
Formal Name: N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]-urea
Purity: ≥98%
Formula Markup: C16H8Br2F6N6O
Formula Weight: 574,1
Shelf life (days): 1460
CAS Number: 426834-69-7
Notes: NS 5806 is an activator of the calcium-independent transient outward potassium current (Ito).{54789} It increases Kv4.3-mediated Ito current amplitudes (EC50 = 5.3 µM), as well as slows Ito current decay in a manner dependent on potassium channel interaction protein 2 (KChIP2), in CHO-K1 cells expressing human Kv4.3. NS 5806 increases Ito currents in isolated rabbit ventricular myocytes (EC50 = 1.6 µM).{54790} It reverses rapid pacing-induced decreases in Ito current recovery and restores the spike-and-dome morphology of the epicardial action potential in ventricular wedge preparations isolated from a dog heart in a model of heart failure.{54791}
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