Formulation: A solid
Formal Name: 5,6,6aR,7-tetrahydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline
Purity: ≥98%
Formula Markup: C19H21NO2
Formula Weight: 295,4
Shelf life (days): 1460
CAS Number: 475-83-2
Notes: Nuciferine is an alkaloid that has been found in N. nucifera and has diverse biological activities.{57616,57617,57618,57619,57620} It acts as a partial agonist at dopamine D2 receptors, as well as an inverse agonist at the serotonin receptor subtype 5-HT7, and an antagonist at the 5-HT2B and 5-HT2C receptors (EC50s = 65.07, 150, 478, and 131 nM, respectively).{57616} Nuciferine is also an antagonist at schistosome Sm.5-HTRL receptors (IC50 = 240 nM) and inhibits 5-HT-induced motility of larval and adult S. mansoni when used at a concentration of 10 µM.{57617} It activates PPARα, PPARβ/δ, and PPARγ transcriptional activity in reporter assays and inhibits IL-6 and TNF-α production induced by LPS in RAW 264.7 cells.{57618} It prevents ferroptotic cell death induced by the GPX4 inhibitor RSL3 in HK-2 and HEK293T cells when used at concentrations of 10, 20, and 40 µM and prevents lipid peroxidation in a mouse model of acute kidney injury.{57619} Dietary administration of nuciferine (15 mg/kg) reduces increases in serum triglyceride, total cholesterol, LDL, and free fatty acid levels, as well as markers of hepatic steatosis, in a mouse model of high-fat diet-induced hyperlipidemia.{57620}
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