Formulation: A lyophilized powder
Formal Name: L-cysteinyl-L-lysyl-L-seryl-(4R)-4-hydroxy-L-prolylglycyl-L-seryl-L-seryl-L-cysteinyl-L-seryl-(4R)-4-hydroxy-L-prolyl-L-threonyl-L-seryl-L-tyrosyl-L-asparaginyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-seryl-L-cysteinyl-L-asparaginyl-(4R)-4-hydroxy-L-prolyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginyl-L-cysteinyl-L-tyrosinamide, cyclic (1→16),(8→19),(15→26)-tris(disulfide), trifluoroacetate salt
Purity: ≥95%
Formula Markup: C120H182N38O43S6 • XCF3COOH
Formula Weight: 3037,4
Shelf life (days): 1460
Notes: ω-Conotoxin GVIA is a peptide originally isolated from the marine mollusk C. geographus that acts as an N-type calcium channel blocker.{38672,38673} It binds to human neocortical, rat hippocampal, and chick brain synaptic plasma membranes (IC50s = 4.6, 60, and 150 pM, respectively, in radioligand binding assays).{38674,38675,38676} ω-Conotoxin GVIA inhibits norepinephrine (Item No. 16673) and acetylcholine (Item No. 23829) release from human neocortical slices (IC50s = 14 and 3 nM, respectively) and calcium influx into chick synaptosomes by 92% when used at a concentration of 0.1 μM.{38674,38675} It blocks electrically-evoked twitch responses of rat vas deferens and guinea pig ileum (IC50s = 9.8 and 55 nM, respectively) but does not affect the postjunctional contractile responses induced by norepinephrine on vas deferens or by carbamoylcholine (carbachol; Item No. 14486) on ileum.{38677} ω-Conotoxin GVIA does not affect potassium-induced contraction of rat aorta at concentrations up to 1 μM.
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