Formulation: A lyophilized powder
Formal Name: L-cysteinyl-L-lysylglycyl-L-lysylglycyl-L-alanyl-L-prolyl-L-cysteinyl-L-arginyl-L-lysyl-L-threonyl-L-methionyl-L-tyrosyl-L-α-aspartyl-L-cysteinyl-L-cysteinyl-L-serylglycyl-L-seryl-L-cysteinylglycyl-L-arginyl-L-arginylglycyl-L-lysyl-L-cysteinamide, cyclic (1→16),(8→20),(15→26)-tris(disulfide), 2,2,2-trifluoroacetate
Purity: ≥95%
Formula Markup: C106H178N40O32S7 • XCF3COOH
Formula Weight: 2749,3
Shelf life (days): 1460
Notes: ω-Conotoxin MVIIC is a peptide originally isolated from the marine mollusk C. magus.{41436} It blocks N-type calcium channels on rat superior cervical ganglions (SCGs) and P-type calcium channels on rat Purkinje neurons (Kds = 30 and ~50 nM, respectively, in the presence of 5 mM barium).{41437} It also blocks Q-type channels in rat CA3 neurons. ω-Conotoxin MVIIC binds to rat brain membranes (IC50 = 0.3 nM) and completely blocks calcium uptake by rat brain synaptosomes when used at a concentration of 2.5 μM in the presence of 5 mM potassium.{41436} It blocks potassium-evoked dopamine (Item No. 21992) release from rat striatal slices (IC50 = ~128 nM) and potassium-evoked calcium-dependent glutamate release from rat brain synaptosomes.{41438,41439}
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