Formulation: A solid
Formal Name: 2-pyridinyl[7-(4-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]-methanone
Purity: ≥98%
Formula Markup: C17H11N5O
Formula Weight: 301,3
Shelf life (days): 1460
CAS Number: 96604-21-6
Notes: Ocinaplon is a GABAA receptor allosteric agonist.{66533} It potentiates GABA-induced currents in X. laevis oocytes expressing α1β2γ2, α2β2γ2, α3β2γ2, and α5β2γ2 subunit-containing recombinant GABAA receptors (EC50s = 3.07, 3.39, 4.59, and 3.79 µM, respectively). Ocinaplon increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats with a minimum effective dose (MED) of 3.1 mg/kg. It decreases clonic convulsions induced by pentylenetetrazole (Item No. 18682) in rats (ED50 = 7.5 mg/kg). Ocinaplon increases punished responding in a squirrel monkey conflict test (MED = 4 mg/kg).