Olmesartan, CAS 144689-24-7

Formulation: A crystalline solid

Formal Name: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid

Purity: ≥98%

Formula Markup: C24H26N6O3

Formula Weight: 446,5

Shelf life (days): 1460

CAS Number: 144689-24-7

Notes: Olmesartan is a non-peptide angiotensin II receptor 1 (AT1) antagonist (IC50 = 0.0077 µM for the bovine adrenal cortex receptor) and an active metabolite of olmesartan medoxomil (Item No. 11614).{20965} It is formed from olmesartan medoxomil by paraoxonase 1 (PON1) in human plasma.{64381} Olmesartan is selective for AT1 over AT2 (IC50 = >100 µM for the bovine cerebellar receptor). It reduces contraction of isolated guinea pig aorta induced by angiotensin II (Item No. 17150; pD2 = 9.9) but not phenylephrine (Item Nos. 17205 / 18619) or potassium chloride. Olmesartan (0.01 and 0.03 mg/kg, i.v.) reduces the angiotensin II-induced pressor response in conscious normotensive rats.

• SKU: CAY23412-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 23412-500
• Green Labware: No
• Package Unit: 500 mg
• Quantity Unit: STK