Formulation: A solid
Formal Name: 4-[1-hydroxy-1-(methyl-d3)ethyl-2,2,2-d3]-2-propyl-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C24H20D6N6O3
Formula Weight: 452,5
Shelf life (days): 1460
CAS Number: 1185144-74-4
Notes: Olmesartan-d6 is intended for use as an internal standard for the quantification of olmesartan (Item No. 23412) by GC- or LC-MS. Olmesartan is a non-peptide angiotensin II receptor 1 (AT1) antagonist (IC50 = 0.0077 µM for the bovine adrenal cortex receptor) and an active metabolite of olmesartan medoxomil (Item No. 11614).{20965} It is formed from olmesartan medoxomil by paraoxonase 1 (PON1) in human plasma.{64381} Olmesartan is selective for AT1 over AT2 (IC50 = >100 µM for the bovine cerebellar receptor). It reduces contraction of isolated guinea pig aorta induced by angiotensin II (Item No. 17150; pD2 = 9.9) but not phenylephrine (Item Nos. 17205 / 18619) or potassium chloride. Olmesartan (0.01 and 0.03 mg/kg, i.v.) reduces the angiotensin II-induced pressor response in conscious normotensive rats.
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