Formulation: A crystalline solid
Formal Name: 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one
Purity: ≥98%
Formula Markup: C21H26N2O5
Formula Weight: 386,4
Shelf life (days): 1460
CAS Number: 868049-49-4
Notes: Olodaterol is a selective agonist of β2-adrenergic receptors (β2-ARs; EC50s = 97.7 and 2,725 nM for human β2- and β1-ARs, respectively).{40022} In vivo, olodaterol completely reverses acetylcholine-induced bronchoconstriction without cardiovascular side effects in guinea pigs. It also exhibits dose-dependent bronchoprotection in a beagle model of acetylcholine-induced bronchoconstriction for a period of 24 hours, indicating potential for once-daily dosing.{40023} Formulations containing olodaterol have been used to treat bronchoconstriction associated with chronic obstructive pulmonary disease.{40024}
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