Formulation: A solid
Formal Name: 3,5-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
Purity: ≥98%
Formula Markup: C17H14O7
Formula Weight: 330,3
Shelf life (days): 1460
CAS Number: 529-40-8
Notes: Ombuin is a flavonoid that has been found in B. balsamifera and has diverse biological activities.{58738,72263,72264,72265} It is an antagonist of M1 muscarinic acetylcholine receptors (mAChRs; Ki = 42 µM in CHO-K1 cells expressing the human receptor).{72263} Ombuin is cytotoxic to HepG2 hepatocellular carcinoma cells (IC50 = 1.5 µg/ml).{72264} In vivo, ombuin (40 mg/kg per day) reduces blood urea and glucose levels, urinary volume and protein levels, serum creatinine levels, renal fibrosis levels, and body weight in a rat model of diabetic nephropathy induced by streptozotocin (STZ; Item No. 13104).{72265}
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