Formulation: A lyophilized powder
Formal Name: L-arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methioninamide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C123H212N44O35S • XCF3COOH
Formula Weight: 2899,3
Shelf life (days): 1460
Notes: Orexin B amide is a hypothalamic neuropeptide that regulates feeding behavior, wakefulness, and behavior under situations of high motivational relevance.{39620} It is an agonist of orexin (OX) receptors with IC50 values of 420 and 36 nM for human recombinant OX1 and OX2 receptors, respectively, expressed in CHO cells.{17937} It induces transient increases in intracellular calcium in CHO cells stably expressing OX1 and OX2 (EC50s = 2,500 and 60 nM, respectively) and in primary rat ventral tegmental area (VTA) dopaminergic neurons.{17937,39617} Orexin B amide stimulates arachidonic acid (Item No. 90010) release from CHO cells expressing human recombinant OX1 (EC50 = 4.17 nM).{39618} It also stimulates food intake in freely feeding mice and goldfish when administered at intracerebroventricular doses of 30 nmol and 10 ng/g, respectively.{17937,39619}
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