Formulation: A crystalline solid
Formal Name: N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-ethanamine, monohydrochloride
Purity: ≥98%
Formula Markup: C18H23NO • HCl
Formula Weight: 305,8
Shelf life (days): 1460
CAS Number: 341-69-5
Notes: Orphenadrine is a muscarinic acetylcholine receptor (mAChR) antagonist (Kds = 48, 213, 120, 170, and 129 nM for M1-M5 receptors, respectively).{25806} Orphenadrine (2-5 mg/kg, i.v.) decreases muscle activity induced by the mAChR agonist oxotremorine in rabbits.{47476} It is also an NMDA receptor antagonist with a Ki value of 6 µM in a radioligand binding assay in human postmortem frontal cortex and an IC50 value of 16.2 µM for inhibiting steady state currents in cultured superior colliculus neurons.{47475} Formulations containing orphenadrine have been used in the treatment of acute painful musculoskeletal conditions, including muscle spasms.
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