Formulation: A solid
Formal Name: 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-ethanol-1,1,2,2-d4
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C24H19ClD4O2
Formula Weight: 382,9
Shelf life (days): 1460
Notes: Ospemifene-d4 is intended for use as an internal standard for the quantification of ospemifene (Item No. 23755) by GC- or LC-MS. Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM).{41365} It binds to estrogen receptor α (ERα) and ERβ (Kis = 380 and 410 nM, respectively). It increases vaginal weight and vaginal epithelial height (ED50s = 0.48 and 0.39 mg/kg per day, respectively) in an ovariectomized rat model of menopause. Ospemifene also increases progesterone receptor protein expression in vaginal epithelium and stroma and inhibits estrogen response element-mediated transactivation induced by 17β-estradiol (Item No. 10006315) in a reporter assay using MCF-7 cells. Formulations containing ospemifene have been used in the treatment of vulvar and vaginal atrophy-induced dyspareunia.
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