Formulation: A solid
Formal Name: 3β-[(6-deoxy-α-L-mannopyranosyl)oxy]-1β,5β,11α,14,19-pentahydroxy-card-20(22)-enolide, hydrate
Purity: ≥98%
Formula Markup: C29H44O12 • XH2O
Formula Weight: 584,7
Shelf life (days): 1460
CAS Number: 340169-01-9
Notes: Ouabain is a cardiac glycoside that has been found in S. gratus and has diverse biological activities.{72165,65175,52442,63309,72166,13089,65170} It inhibits the Na+/K+-ATPase isoforms α1β1 and α2β1 and human-ether-a-go-go (hERG), also known as Kv11.1 (IC50s = 97, 90, and 15.2 nM, respectively).{65175,52442} Ouabain reduces the proliferation of PC3 prostate cancer and U937 lymphoma cells (EC50s = 210 and 94 nM, respectively).{63309} It inhibits the cytopathic effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infected Vero cells (IC50 = in vivo.{65170} Formulations containing ouabain have been used in the treatment of atrial fibrillation, atrial flutter, and heart failure.
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