Formulation: A solid
Formal Name: 3β-[(8-carboxy-1-oxooctyl)oxy]-cholest-5-en-7-one
Purity: ≥80%
Formula Markup: C36H58O5
Formula Weight: 570,8
Shelf life (days): 730
CAS Number: 352523-18-3
Notes: oxLig-1 is an ω-carboxylated 7-ketocholesteryl ester and a lipid component of oxidized LDL (oxLDL).{13442} It binds to the ligand-binding domain of peroxisome proliferator-activated receptor γ (PPARγ), an effect that can be reversed by the PPARγ agonist troglitazone (Item No. 71750), and also binds to CD36, also known as scavenger receptor B2, when used at a concentration of 50 µg/ml.{49891,49893} oxLig-1 (20 µg/ml) increases cholesterol efflux and protein levels of liver X receptor α (LXRα) and ATP-binding cassette transporter 1 subfamily A (ABCA1) in THP-1 macrophages. Liposomes containing oxLig-1 and complexed with apolipoprotein H, also known as β2-glycoprotein I (β2-GPI), bind to an anti-apolipoprotein H antibody, which mediates uptake by J774A.1 macrophages.{13442} oxLig-1 decreases intracellular lipid accumulation induced by oleic acid (Item Nos. 90260 / 24659) in HepG2 cells, as well as hepatic lipid accumulation in mice fed a high-fat diet.{49893} Serum levels of IgG autoantibodies targeting a complex of oxLig-1 and apolipoprotein H are increased in patients with antiphospholipid syndrome with a history of arterial thrombosis.{49892}
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