Formulation: A solid
Formal Name: 1-[4-(1-pyrrolidinyl)-2-butyn-1-yl]-2-pyrrolidinone, 2E-butenedioate (2:3)
Purity: ≥95%
Formula Markup: C12H18N2O • 3/2C4H4O4
Formula Weight: 380,4
Shelf life (days): 1460
CAS Number: 17360-35-9
Notes: Oxotremorine is an agonist of muscarinic acetylcholine receptors (mAChRs).{66053} It binds to M1, M2, M3, and M4 mAChRs (Kis = 3.31, 9.33, 5.24, and 7.08 µM, respectively, for the human receptors). It inhibits acetylcholine (ACh; Item No. 23829) release in rat cerebral cortical slices when used at a concentration of 10 µM, an effect that can be reversed by the non-selective mAChR antagonist atropine (Item No. 12008).{66054} Oxotremorine induces tremors, salivation, and lacrimation in mice (ED50s = 0.11, 0.22, and 0.28 mg/kg).{66055} It induces analgesia in the hot plate test in mice when administered at a dose of 0.5 mg/kg.{66056} Oxotremorine has been used to induce parkinsonian symptoms as a model of Parkinson’s disease in mice.{66057}
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