Oxprenolol-d7, CAS 1189805-10-4

Formulation: A solid

Formal Name: 1-(2-(allyloxy)phenoxy)-3-((propan-2-yl-d7)amino)propan-2-ol

Purity: ≥98%

Formula Markup: C15H16D7NO3

Formula Weight: 272,4

Shelf life (days): 1460

CAS Number: 1189805-10-4

Notes: Oxprenolol-d7 is intended for use as an internal standard for the quantification of oxprenolol (Item No. 16080) by GC- or LC-MS. Oxprenolol is an orally bioavailable β-adrenergic receptor (β-AR) antagonist (Ki = 7.10 nM in a radioligand binding assay using rat heart tissue).{41183} It is non-selective and binds to both β1- and β2-ARs (Kds = 2.09 and 1.35 nM in isolated rat heart and uterus, respectively).{41184} Oxprenolol is selective for β-ARs over serotonin (5-HT) receptors in rat sarcolemmal membrane preparations (IC50s = 4.13 and 23,300 nM, respectively), but it binds to 5-HT1A receptors in rat hippocampus and 5-HT1B in rat striatum (Kis = 94.2 and 642 nM, respectively).{41185,41186} Formulations containing oxprenolol have been used to treat hypertension and angina pectoris.{41187}

• SKU: CAY33274-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 33274-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: GC-MS, LC-MS, Isotopenmarkierung