Formulation: A crystalline solid
Formal Name: 2-[(2-cyclohexyl-2-hydroxy-2-phenylacetyl)oxy]-N,N-diethyl-N-methyl-ethanaminium, monobromide
Purity: ≥98%
Formula Markup: C21H34NO3 • Br
Formula Weight: 428,4
Shelf life (days): 1460
CAS Number: 50-10-2
Notes: Oxyphenonium is an antagonist of muscarinic acetylcholine receptors that binds to muscarinic receptors on isolated guinea pig atria and ileum (Kds = 0.11 and 0.17 nM, respectively).{36510} In vivo, oxyphenonium reverses carbaminocholine- and acetylcholine-induced decreases in blood pressure in anesthetized cats (ED50s = 0.591 and 1 μg/kg, respectively).{36511} It decreases rumenal ulcer formation in rats and suppresses insulin-induced gastric secretion in dogs with gastric fistulas.{36512} Oxyphenonium also prevents form-deprivation myopia (FDM) in a chick model of experimental myopia.{36513} Formulations containing oxyphenonium have been used to treat peptic ulcers.
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