Formulation: A solid
Formal Name: 1,1'-(2,2-dichloroethylidene)bis[4-chloro-benzene]
Purity: ≥98%
Formula Markup: C14H10Cl4
Formula Weight: 320
Shelf life (days): 1460
CAS Number: 72-54-8
Notes: p,p’-DDD is a metabolite of the organochlorine pesticide DDT.{36698} It is an agonist at estrogen receptor α (ERα) and ERβ, increasing transactivation with 20% relative effective concentrations (REC20) of 3.2 and 2.4 µM, respectively, in CHO-K1 cells expressing the human receptors.{42200} It inhibits DHT-induced androgen receptor transcription with a 20% relative inhibitory concentration (RIC20) of 0.71 µM. p,p'-DDD increases apoptosis in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations of 100 and 150 µg/ml.{36699} Blood levels of p,p’-DDD and the level of PBMC apoptosis are increased in children exposed to DDT compared with unexposed children. It is not considered lethal to hamsters (LD50 = ~5,000 mg/kg) but is to rats (LD50 = 3,750 mg/kg).{36700}
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