Formulation: A solid
Formal Name: 1,1'-(2,2-dichloroethenylidene)bis[4-chloro-benzene]
Purity: ≥98%
Formula Markup: C14H8Cl4
Formula Weight: 318
Shelf life (days): 1460
CAS Number: 72-55-9
Notes: p,p'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT.{39801} It accumulates in smallmouth buffalo, channel catfish, and largemouth bass as well as sediment in the Huntsville Spring Branch-Indian Creek tributary system surrounding a DDT manufacturing plant where it is considered a persistent organic pollutant (POP). p,p'-DDE inhibits estrogen binding to rainbow trout estrogen receptors (rtERs) with an IC50 value of 8 µM.{12991} It induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles.{39802} p,p'-DDE (50-100 µM) also decreases ATP levels, the proportion of sperm with high mitochondrial membrane potential, and motility of human sperm in vitro.{42280}
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