P1075, CAS 60559-98-0

Formulation: A crystalline solid

Formal Name: N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridinyl-guanidine

Purity: ≥98%

Formula Markup: C12H17N5

Formula Weight: 231,3

Shelf life (days): 1460

CAS Number: 60559-98-0

Notes: P1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-Kir6) with an EC50 value of 45 nM for SUR2B-Kir6 channel activation.{38539} It is highly selective for SUR2 over SUR1 isoforms (IC50s = 9-46 nM and 1.02 mM, respectively, in a radioligand binding assay). P1075 increases outflow facility, a marker of reduced intraocular pressure, in human eye anterior segments ex vivo.{38540} It also reduces infarct size in isolated rabbit hearts via activation of mitochondrial ATP-sensitive potassium channels (KATP; EC50s = 60-90 nM).{38541}

• SKU: CAY21849-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 21849-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK