Formulation: A crystalline solid
Formal Name: N-[2-hydroxy-1-(hydroxymethyl)ethyl]-hexadecanamide
Purity: ≥95%
Formula Markup: C19H39NO3
Formula Weight: 329,5
Shelf life (days): 365
CAS Number: 126127-31-9
Notes: Palmitoyl serinol is a derivative of 2-palmitoyl glycerol (2-PG; Item No. 17882), an endogenous fatty acid ester that potentiates the signaling and in vivo activity induced by the endocannabinoid 2-arachidonoyl glycerol (2-AG; Item No. 62160).{9610,10671, 9575} It is a metabolite of human commensal bacteria and an agonist of GPR119, increasing cAMP levels in HEK293 cells expressing GPR119 (EC50 = 9 µM).{39726} Palmitoyl serinol (25 µM) reduces IL-4-induced decreases in the levels of long-chain fatty acid-containing ceramides in IL-4-stimulated HaCaT keratinocytes, an effect that can be blocked by the cannabinoid receptor 1 (CB1) antagonist AM-251.{62556} It also binds to PKCζ and induces apoptosis in F-11 neuroblastoma cells, an effect that can be blocked by the PKCζ inhibitor Gö 6983 (Item No. 13311).{8954}
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