Formulation: A solid
Formal Name: L-phenylalanyl-L-arginyl-L-lysyl-L-lysyl-L-tryptophyl-L-asparaginyl-L-lysyl-L-tryptophyl-L-alanyl-L-leucyl-L-seryl-L-argininamide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C77H119N25O14 • XCF3COOH
Formula Weight: 1618,9
Shelf life (days): 1460
Notes: Proadrenomedullin N-terminal 12 peptide (PAMP-12) is an endogenous peptide fragment found in the adrenal medulla that corresponds to amino acids 9-20 of human PAMP-20 and is involved in hypotension.{69443,42630,69444} It is an agonist of MAS-related G protein-coupled receptor family member X2 (MRGPRX2).{42630} PAMP-12 inhibits forskolin-induced cAMP accumulation in CHO cells expressing human MRGPRX2 (EC50 = 57.2 nM). It selectively induces calcium mobilization in CHO cells expressing MRGPRX2 (EC50 = 41 nM) over those expressing MRGPRX1, MRGPRX3, or MRGPRX4 at 1 µM. PAMP-12 is an antagonist of nicotinic acetylcholine receptors (nAChRs) that inhibits carbachol-induced catecholamine release (IC50 = 1.3 µM) and calcium and sodium influx (IC50s = 0.39 and 0.87 µM, respectively), but not histamine-induced catecholamine release or calcium and sodium influx (IC50s = >1 µM for all), in primary bovine adrenal chromaffin cells.{69444} It reduces mean arterial blood pressure in normotensive rats when administered at doses ranging from 10 to 50 nmol/kg.{69443}
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