PAR3 (1-6) amide (human) (trifluoroacetate salt)

Formulation: A solid

Formal Name: L-threonyl-L-phenylalanyl-L-arginylglycyl-L-alanyl-L-prolinamide, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C29H46N10O7 • XCF3COOH

Formula Weight: 646,7

Shelf life (days): 1460

Notes: PAR3 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) and PAR2 that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) amide activates PAR1 and PAR2 in Jurkat and HEK cells, inducing calcium accumulation in Jurkat cells, which is reduced following desensitization with the PAR1- and PAR2-selective peptide agonist SFLLR-NH2.{49046} It decreases the expression of CDC42 in wild-type, but not PAR3 knockdown, PANC-1 cells and reduces invasion of PANC-1 cells.{47510}

• SKU: CAY28201
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 28201-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK