Formulation: A solid
Formal Name: L-seryl-L-phenylalanyl-L-asparaginylglycylglycyl-L-prolinamide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C25H36N8O8 • XCF3COOH
Formula Weight: 576,6
Shelf life (days): 1460
Notes: PAR3 (1-6) amide is a synthetic hexapeptide that corresponds to amino acid residues 1-6 of the amino terminal tethered ligand sequence of mouse proteinase-activated receptor 3 (PAR3) and residues 38-43 of the full-length sequence. PAR3 (1-6) amide activates PAR1 and PAR2, but not PAR3 or PAR4.{49045,49046} It does not induce thrombin signaling in COS-7 cells expressing PAR3, PAR4, or both receptors at concentrations less than or equal to 500 µM, however, it does activate PAR1 and PAR2 in a cross-desensitization assay in Jurkat T cells when used at concentrations of 500 and 1,000 µM.{49045,49046} PAR3 (1-6) increases calcium levels in Kirsten virus-transformed rat kidney (KNRK) cells expressing rat or human PAR2, with a higher potency for rat PAR2.
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