Formulation: A solid
Formal Name: glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl-L-arginine, acetate
Purity: ≥98%
Formula Markup: C35H55N11O9 • XC2H4O2
Formula Weight: 773,9
Shelf life (days): 1460
Notes: PE 22-28 is a peptide inhibitor of the two-pore domain potassium channel K2P2.1/TREK1 (IC50 = 0.1 nM in HEK293 cells expressing the human channel) and a fragment of spadin (Item No. 36762).{72321} It is selective for K2P2.1/TREK1 over K2P10.1 /TREK2, K2P13.1/TRAAK, K2P18.1/TRESK, and K2P3.1/TASK1 in HEK293 cells expressing the human channels at 100 nM. PE 22-28 (4 µg/kg for four days) increases neurogenesis and the levels of postsynaptic density protein 95 (Psd-95), a measure of increased synaptogenesis, in isolated mouse hippocampi. It decreases immobility in the forced swim test, latency to feed in the novelty-suppressed feeding test, and the time to escape in the Porsolt learned helplessness test in mice when administered at a dose of 0.3 µg/kg for four days.
English
Deutsch
