Formulation: A solid
Formal Name: (2S)-1-(2-cyclopentylphenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol, hemisulfate
Purity: ≥95%
Formula Markup: C18H29NO2 • 1/2H2SO4
Formula Weight: 340,5
Shelf life (days): 1460
CAS Number: 38363-32-5
Notes: Penbutolol is an antagonist of β-adrenergic receptors (β-ARs; IC50 = 2.8 nM) and the serotonin (5-HT) receptor subtype 5-HT1A (IC50 = 9.9 nM).{53262} It inhibits adenylate cyclase activity induced by the β-AR agonist isoprenaline (isoproterenol; Item No. 15592) in guinea pig myocardial membranes with a Ki value of 2.4 nM.{53263} Penbutolol reduces basal renin activity and blood pressure in spontaneously hypertonic rats.{53264} It decreases isolation-induced aggressive behavior in mice (ED50 = 56 µmol/kg) and reverses reductions in aggression induced by 8-hydroxy-DPAT (Item No. 22608) and TFMPP with ED50 values of 8.1 and 2.1 µmol/kg, respectively.{53262} Formulations containing penbutolol were previously used in the treatment of arterial hypertension.
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