Formulation: A crystalline solid
Formal Name: 1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol
Purity: ≥98%
Formula Markup: C28H27ClF5NO
Formula Weight: 524
Shelf life (days): 1460
CAS Number: 26864-56-2
Notes: Penfluridol is a first generation typical antipsychotic that binds to dopamine receptors (IC50 = 5.6 nM).{42533} It binds to dopamine D4 receptors and also to serotonin (5-HT) receptors (Kis = 31 and 63.1 nM, respectively).{42534,42535} Penfluridol (1.25 and 2.5 mg/kg) inhibits stereotypic behavior induced by apomorphine (Item No. 16094) in cynomolgus monkeys.{42536} It also inhibits proliferation of triple-negative breast cancer cells (TNBCs; IC50s = 6-8 µM), as well as inhibits migration and invasion of TNBCs and decreases the expression of integrin α6 and β4.{42537} Penfluridol reduces tumor growth and metastasis in a 4T1 orthotopic mouse model when administered at a dose of 10 mg/kg per day.
English
Deutsch
