PEPA, CAS 141286-78-4

PEPA, CAS 141286-78-4
SKU
CAY29190-10
Packaging Unit
10 mg
Manufacturer
Cayman Chemical

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Formulation: A crystalline solid

Formal Name: 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]-acetamide

Purity: ≥98%

Formula Markup: C16H16F2N2O4S2

Formula Weight: 402,4

Shelf life (days): 1460

CAS Number: 141286-78-4

Notes: PEPA is a positive allosteric modulator (PAM) of AMPA receptors.{52115} It selectively increases glutamate-induced currents in X. laevis oocytes expressing the flop isoforms of the AMPA receptor subunits glutamate receptor 3 (GluR3) and GluR4 over the flip isoforms of these subunits at 200 µM. PEPA (10 mg/kg) decreases the latency to find the platform in the Morris water maze, indicating reversal of memory deficits, in a rat model of memory impairment induced by middle cerebral artery occlusion (MCAO).{52116} It decreases freezing time in a contextual fear freezing paradigm in mice when administered at a dose of 30 mg/kg.{52117}
More Information
SKU CAY29190-10
Manufacturer Cayman Chemical
Manufacturer SKU 29190-10
Green Labware No
Package Unit 10 mg
Quantity Unit STK
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