Formulation: A solid
Formal Name: 4-[3-(2-chloro-10H-phenothiazin-10-yl-1,3,7,9-d4)propyl]-1-piperazineethanol
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C21H22ClD4N3OS
Formula Weight: 408
Shelf life (days): 1460
CAS Number: 155593-75-2
Notes: Perphenazine-d4 is intended for use as an internal standard for the quantification of perphenazine (Item No. 20735) by GC- or LC-MS. Perphenazine is a typical antipsychotic.{24253} It binds to dopamine D2, α1A-, α2A-, α2B-, and α2C-adrenergic, M3 muscarinic, and histamine H1 receptors (Kis = 1.4, 10, 1,848, 104.9, 85.2, 810.5 and 8 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 421, 5.6, 132, 17, and 23 nM, respectively). Perphenazine (1, 5, and 10 mg/kg) enhances morphine-induced analgesia in the tail-flick and hot plate tests in rats.{57432} It reduces cannibalism in female mice when administered at doses of 2 and 4 mg/kg.{57431} Formulations containing perphenazine have been used in the treatment of schizophrenia and psychosis.
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