PF-04449913, CAS 1095173-27-5

Formulation: A crystalline solid

Formal Name: N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)-urea

Purity: ≥98%

Formula Markup: C21H22N6O

Formula Weight: 374,4

Shelf life (days): 1460

CAS Number: 1095173-27-5

Notes: PF-04449913 is an orally available Hedgehog pathway inhibitor that acts by binding Smoothened (Smo) and blocking signal transduction (IC50 = 5 nM).{33585} It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells and in an in vivo Drosophila model.{33586,33584}

• SKU: CAY9002936-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 9002936-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK