PF-04995274, CAS 1331782-27-4

Formulation: A crystalline solid

Formal Name: tetrahydro-4-[[4-[[[4-[[(3R)-tetrahydro-3-furanyl]oxy]-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-2H-pyran-4-ol

Purity: ≥98%

Formula Markup: C23H32N2O6

Formula Weight: 432,5

Shelf life (days): 1460

CAS Number: 1331782-27-4

Notes: PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay).{52049} It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg.

• SKU: CAY28776-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 28776-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK