PF-4136309, CAS 1341224-83-6

Formulation: A solid

Formal Name: N-[2-[(3S)-3-[[trans-4-hydroxy-4-[5-(2-pyrimidinyl)-2-pyridinyl]cyclohexyl]amino]-1-pyrrolidinyl]-2-oxoethyl]-3-(trifluoromethyl)-benzamide

Purity: ≥98%

Formula Markup: C29H31F3N6O3

Formula Weight: 568,6

Shelf life (days): 1460

CAS Number: 1341224-83-6

Notes: PF-4136309 is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50s = 5.2, 13, and 17 nM for the human, rat, and mouse receptors, respectively).{53022} It also inhibits the voltage-gated potassium channel subtype Kv11.1 by 35% when used at a concentration of 10 µM. PF-4136309 decreases isolated human monocyte chemotaxis induced by chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 3.9 nM.

• SKU: CAY21965-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 21965-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK