Formulation: A crystalline solid
Formal Name: 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
Purity: ≥99%
Formula Markup: C14H20N2O2
Formula Weight: 248,3
Shelf life (days): 730
CAS Number: 13523-86-9
Notes: Pindolol is an antagonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 2.6 and 4.8 nM, respectively) and a partial agonist of the β3-AR, stimulating adenylyl cyclase in membranes of cells expressing the human receptor.{37170,25395} It is also an antagonist of the serotonin 5-HT1A receptor (Ki = 81.1 nM for inhibition of 5-HT-stimulated GTPγS binding).{39331} Pindolol inhibits isoproterenol-induced tachycardia in anesthetized cats (ED50 = 1.8 µg/kg).{37171} It also decreases mean blood pressure in conscious spontaneously hypertensive rats when administered at a dose of 30 mg/kg per day, but concomitantly increases heart rate.{41850} Formulations containing pindolol have been used in the treatment of hypertension.
English
Deutsch
