Formulation: A solid
Formal Name: L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-leucine, cyclic (4→12),(7→15)-bis(disulfide), monoacetate
Purity: ≥98%
Formula Markup: C65H104N18O26S4 • C2H4O2
Formula Weight: 1741,9
Shelf life (days): 1460
CAS Number: 1075732-84-1
Notes: Plecanatide is a peptide agonist of the guanylate cyclase C receptor.{62429} It stimulates cGMP production in T84 colon cancer cells (EC50 = 170 nM). Plecanatide (10 ppm in the diet) reduces increases in the number of neoplastic colon epithelial cells expressing Ki-67, a marker of cell proliferation, induced by dextran sulfate (DSS; Item No. 23250) in cancer-prone Apc+/Min-FCCC mice.{62430} It suppresses trinitrobenzenesulfonic acid-induced increases in abdominal contractions in a rat model of visceral hypersensitivity when administered at doses of 0.01 and 0.05 mg/kg.{62431} Formulations containing plecanatide have been used in the treatment of chronic idiopathic constipation.
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