Formulation: A solid
Formal Name: 4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid, monohydrochloride
Purity: ≥98%
Formula Markup: C29H24F3NO2 • HCl
Formula Weight: 512
Shelf life (days): 1460
CAS Number: 1992047-65-0
Notes: PPTN is an antagonist of the purinergic P2Y14 receptor.{66094} It inhibits forskolin-induced cyclic AMP accumulation in C6 cells expressing human P2Y14 (EC50 = ~10 nM) but not CHO cells expressing P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 at 1 µM. PPTN (5 µM) inhibits UDP-glucose-induced IL-1β and chemokine (C-C motif) ligand 2 (CCL2) secretion, as well as ERK, JNK, and p38 MAPK phosphorylation in isolated rat satellite glial cells (SGCs).{66095} Trigeminal administration of PPTN (5 and 10 µM) reduces mechanical hyperalgesia induced by complete Freund’s adjuvant (CFA) in rats.{66096}
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