Formulation: A solid
Formal Name: 25-L-proline-28-L-proline-29-L-proline-amylin (human), monoacetate hydrate
Purity: ≥95%
Formula Markup: C171H267N51O53S2 • XC2H4O2 [XH2O]
Formula Weight: 3949,4
Shelf life (days): 1460
CAS Number: 196078-30-5
Notes: Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin (Item Nos. 24274 / 24275) that contains proline residues substituted at positions 25, 28, and 29.{46043} It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively).{46044} Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner.{46045} In vivo, pramlintide (200 pg/kg) reduces brain levels of amyloid-β (1-40) (Aβ40; Item No. 21617) and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer's disease.{46046}
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