Formulation: A solid
Formal Name: N-(1-methyl-2-phenylethyl)-γ-phenyl-benzenepropanamine
Purity: ≥98%
Formula Markup: C24H27N
Formula Weight: 329,5
Shelf life (days): 1460
CAS Number: 390-64-7
Notes: Prenylamine is a calcium channel inhibitor.{53153} It inhibits the plasma membrane Ca2+ ATPase (PMCA) in isolated and purified pig cardiac sarcolemma.{53149} It binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 µM and inhibits CaM-activated cAMP phosphodiesterase (PDE) activity when used at concentrations ranging from 10 to 50 µM, an effect that is negatively associated with the concentration of calmodulin.{53149,53150} Prenylamine (30 μM) shortens action potential duration and decreases the amplitude of peak calcium currents in single guinea pig ventricular myocytes in the absence and presence of propranolol (Item No. 23349) and phentolamine (Item No. 16135).{53151} Prenylamine (50 mg/kg) decreases epinephrine, serotonin, and dopamine levels in rat brain.{53152} It also decreases epinephrine levels in rat heart. It protects anesthetized rats from coronary artery occlusion-induced arrhythmia when administered at a dose of 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole when administered at a dose of 5 mg/kg.{53154}
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