Formulation: A solid
Formal Name: 4-[3-(methylsulfonyl)phenyl]-1-propyl-piperidine
Purity: ≥95%
Formula Markup: C15H23NO2S
Formula Weight: 281,4
Shelf life (days): 1460
CAS Number: 346688-38-8
Notes: Pridopidine is a ligand of sigma non-opioid intracellular receptor 1 (σ1 receptor) and a dopaminergic stabilizer.{65845,22062} It binds to the σ1 receptor and dopamine D2 receptor in the high-affinity state (Kis = 81.3 and 7,521 nM, respectively). Pridopidine (100 µmol/kg) increases striatal 3,4-dihydroxyphenylacetic acid (DOPAC) levels and locomotor activity, as well as inhibits amphetamine-induced locomotor activity, in rats.{22062} It improves motor function and reduces striatal mutant huntingtin (mHtt) aggregates in the R6/2 mouse model of Huntington’s disease when administered at doses of 5 or 6 mg/kg.{65846} Pridopidine (30 mg/kg) prevents muscle atrophy and the loss of innervated neuromuscular junctions in the SOD1-G93A mouse model of amyotrophic lateral sclerosis (ALS).{65847}
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