Formulation: A solid
Formal Name: N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide
Purity: ≥98%
Formula Markup: C15H16Cl3N3O2
Formula Weight: 376,7
Shelf life (days): 1460
CAS Number: 67747-09-5
Notes: Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.{41691} It inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM).{30331} Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM).{41692} In vivo, prochloraz (250 mg/kg) reduces the weight of seminal vesicles in intact male rats and of seminal vesicles, ventral prostate, and bulbourethral glands in castrated testosterone-treated male rats.{41693} It also reduces testosterone levels and increases progesterone levels in male rat pups following administration of a 30 mg/kg per day dose to pregnant females during gestation.
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