Formulation: A solid
Formal Name: 2-chloro-10-[3-(4-methyl-1-piperazinyl-d8)propyl]-10H-phenothiazine, dihydrochloride
Purity: ≥98%
Formula Markup: C20H16ClD8N3S • 2HCl
Formula Weight: 454,9
Shelf life (days): 1460
CAS Number: 2930627-64-6
Notes: Prochlorperazine-d8 is intended for use as an internal standard for the quantification of prochlorperazine (Item No. 20742) by GC- or LC-MS. Prochlorperazine is a dopamine D2 receptor antagonist with Ki values of 4.7 and 2.9 nM for rat recombinant D2 receptors in CHO cells and rat striatal membranes, respectively.{30683,39858} It also binds to rat recombinant D3 receptors expressed in CHO cells (Ki = 35 nM) and to the serotonin (5-HT) receptor subtype 5-HT3 in N1E-115 mouse neuroblastoma cell membranes (Ki = 1,200 nM).{30683,39857} Prochlorperazine (2 mg/kg) increases the latency to paw licking in a hot plate test, indicating analgesia, an effect that is blocked by antisense oligonucleotides against the M1 muscarinic receptor.{39859} It also inhibits emesis induced by apomorphine (Item No. 16094) in dogs (ED50 = 0.34 mg/kg).{39860} Formulations containing prochlorperazine have been used in the treatment of psychotic disorders and as antiemetics.
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