Formulation: A solid
Formal Name: 1-(2-(2-hydroxy-3-(propylamino)propoxy-1,1,2,3,3-d5)phenyl)-3-phenylpropan-1-one, monohydrochloride
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C21H22D5NO3 • HCl
Formula Weight: 382,9
Shelf life (days): 1460
CAS Number: 1346605-05-7
Notes: Propafenone-d5 is intended for use as an internal standard for the quantification of propafenone (Item No. 21871) by GC- or LC-MS. Propafenone is a class I antiarrhythmic agent.{34127} It inhibits calcium currents (ICa) in isolated guinea pig ventricular myocytes (IC50 = 5 µM), as well as ATP-sensitive potassium currents (IKATP) in isolated rabbit atrial and ventricular monocytes (IC50s = 1.26 and 4.94 µM, respectively).{34127,34126} Propafenone also blocks sodium (INa), potassium (IK), and transient outward potassium currents in various cardiac cells.{34126,34128,31430} In vivo, propafenone (2 and 3 mg/kg, i.v.) reverses sinus rhythm in a dog model of barium chloride-induced ventricular arrhythmia.{57430} Formulations containing propafenone have been used in the treatment of cardiac arrhythmias.
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