Formulation: A solid
Formal Name: 3,7-dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6-dione
Purity: ≥95%
Formula Markup: C15H22N4O3
Formula Weight: 306,4
Shelf life (days): 1460
CAS Number: 55242-55-2
Notes: Propentofylline is a xanthine derivative and neuroprotective agent.{53286,53287} It increases NGF production in primary mouse astroglia when used at concentrations ranging from 0.12 to 3.33 mM, with the maximum increase observed at 1.11 mM.{53286} Propentofylline (20 µg/ml) reduces cell death induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in primary rat hippocampal neurons.{53287} Intravenous infusion of propentofylline (0.01, 0.05, and 0.1 mg/kg per minute) reduces infarct volume in a rat model of ischemic brain damage induced by permanent middle cerebral artery occlusion (MCAO) when administered following MCAO.{53288} It inhibits cAMP phosphodiesterases, is an antagonist of adenosine A1 and A2 receptors, and binds to adenosine transporters.{53289,53290}
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