Formulation: A solid
Formal Name: 1-[(1-methylethyl)amino]-3-(1-naphthalenyl-2,3,4,5,6,7,8-d7-oxy)-2-propanol
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C16H14D7NO2
Formula Weight: 266,4
Shelf life (days): 1460
CAS Number: 344298-99-3
Notes: (±)-Propranolol-d7 is intended for use as an internal standard for the quantification of propranolol (Item Nos. 23349 / 17291) by GC- or LC-MS. (±)-Propranolol is a β-adrenergic receptor (β-AR) antagonist (Kds = 6.91, 0.832, and 117.49 nM for human β1-, β2-, and β3-ARs, respectively).{25151} It reduces mean blood pressure, resting heart rate, and contractility and increases AV conduction time in dogs.{30090} (±)-Propranolol restores normal sinus rhythm in dogs with ouabain-induced arrhythmias (ED50 = 3.8 mg/kg).{39376} It also acts as a non-specific serotonin receptor antagonist, reducing tranylcypromine/L-tryptophan-induced hyperactivity in rats.{25891} Formulations containing (±)-propranolol have been used for the treatment of hypertension, angina pectoris, and cardiac ischemia.
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