Formulation: A solid
Formal Name: N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine, monohydrochloride
Purity: ≥98%
Formula Markup: C19H21N • HCl
Formula Weight: 299,8
Shelf life (days): 1460
CAS Number: 1225-55-4
Notes: Protriptyline is a tricyclic antidepressant.{22877} It binds to the norepinephrine and serotonin (5-HT) transporters with Kd values of 1.41 and 19.6 nM, respectively. Protriptyline also binds to histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors (Kds = 25, 25, and 130 nM, respectively).{25914} It inhibits norepinephrine uptake into rat whole brain and hypothalamic synaptosomes (IC50s = 12 and 0.55 μM, respectively) and 5-HT uptake into rat whole brain synaptosomes (IC50 = 5.5 μM).{54252} Protriptyline (1 mg/kg, i.v.) inhibits food-induced cataplexy in narcoleptic dogs.{46726} Formulations containing protriptyline have been used in the treatment of depression.
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