PRX-08066, CAS 866206-54-4

Formulation: A crystalline solid

Formal Name: 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-benzonitrile

Purity: ≥95%

Formula Markup: C19H17ClFN5S

Formula Weight: 401,9

Shelf life (days): 1460

CAS Number: 866206-54-4

Notes: PRX-08066 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2B.{52798} It binds to 5-HT2B receptors (Ki = 3.4 nM) and inhibits 5-HT-induced MAPK activation and thymidine incorporation in CHO cells expressing human 5-HT2B (IC50s = ~12 and ~3 nM, respectively). PRX-08066 (50 and 100 mg/kg) reduces peak pulmonary arterial pressure and right ventricular hypertrophy in a rat model of pulmonary hypertension induced by monocrotaline (MCT; Item No. 16666).

• SKU: CAY31477-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 31477-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK