Psora 4, CAS 724709-68-6

Formulation: A crystalline solid

Formal Name: 4-(4-phenylbutoxy)-7H-furo[3,2-g ][1]benzopyran-7-one

Purity: ≥98%

Formula Markup: C21H18O4

Formula Weight: 334,4

Shelf life (days): 1460

CAS Number: 724709-68-6

Notes: Psora 4 is an inhibitor of voltage-gated potassium channels (Kv1.3; EC50 = 3 nM).{51189} It is selective for Kv1.3 over Kv1.1, Kv1.2, Kv1.4, Kv1.7, and Kv3.1 channels (EC50s = 62, 49, 202, 100, and 1,500 nM, respectively) but does inhibit the Kv1.5 channel (EC50 = 7.7 nM). Psora 4 selectively binds to the C-type inactivated state of the Kv1.3 channel and inhibits potassium current in a use-dependent manner. It has immunosuppressive activity, inhibiting proliferation of human and rat myelin-specific effector memory T cells in vitro (TEM cells; EC50s = 25 and 60 nM, respectively).

• SKU: CAY28389-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 28389-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK