Formulation: A solid
Formal Name: 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl-d8)ethoxy]-ethanol, 2E-butenedioate
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C21H17D8N3O2S • C4H4O4
Formula Weight: 507,6
Shelf life (days): 1460
CAS Number: 1185247-12-4
Notes: Quetiapine-d8 is intended for use as an internal standard for the quantification of quetiapine (Item No. 14152) by GC- or LC-MS. Quetiapine is an atypical, second generation antipsychotic compound.{26444,23393,22060} It has effects at multiple receptors, antagonizing dopamine D1, D2, and D3 receptors (Kis = 994, 379, and 340 nM, respectively), serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors (Kis = 394, 118, and 307 nM, respectively), and α1A, α1B, and α2C adrenergic receptors (Kis = 22, 15, and 29 nM, respectively).{25511,24253} Quetiapine also potently antagonizes the histamine H1 receptor (Ki = 11 nM).{24253}
English
Deutsch
